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Home MEDICINE

MEDICINE

category medicine Scientific European
Attribution: NIMH, Public domain, via Wikimedia Commons
There are reports of outbreaks of Human Metapneumovirus (hMPV) infection in many parts of the world. In the backdrop of recent COVID-19 pandemic, hMPV outbreaks in several countries are causing concern among the people. However, the observed increase in...
Concizumab (commercial name, Alhemo), a monoclonal antibody was approved by the FDA on 20 December 2024 for prevention of bleeding episodes in patients with hemophilia A with factor VIII inhibitors or hemophilia B with factor IX inhibitors. It had...
Multidrug resistant tuberculosis (MDR TB) affects half a million people each year.  Levofloxacin is advised for preventive treatment based on observational data, however evidence from large scale clinical trial is unavailable. TB CHAMP and V-QUIN, two phase 3 clinical...
Ryoncil has been approved for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), a life-threatening condition that may result from blood stem cell transplantation performed to replace recipient's defective stem cells in certain types of blood cancers, blood disorders...
A recent study has estimated disease frequency of herpes simplex virus (HSV) infections and genital ulcer disease (GUD). The estimates suggest that about 846 million people aged 15–49 years were living with genital herpes infections in 2020, which is...
Researchers have developed a urine test that can detect lung cancer at an early stage using a novel approach. It uses an injectable protein probe to detect the presence of senescent cells in the lung though interaction with a...
On October 22, 2024, a surgical team performed the first fully robotic double lung transplant on a 57-year-old woman with chronic obstructive pulmonary disease (COPD) using the Da Vinci Xi robotic system at each stage. The minimally invasive procedure...
Asciminib (Scemblix) has been approved for adult patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase (CP). The accelerated approval was granted by the FDA on 29 October 2024.   Earlier, asciminib was approved by FDA...
On 11 October 2024, Hympavzi (marstacimab-hncq), a human monoclonal antibody targeting “tissue factor pathway inhibitor” received US FDA’s approval as a new drug for prevention of bleeding episodes in individuals with hemophilia A or hemophilia B.   Earlier, on 19 September...
Cobenfy (also known as KarXT), a combination of the drugs xanomeline and trospium chloride, has been studied to be effective for the treatment of schizophrenia and has been approved by the FDA as an antipsychotic in September 20241. This...
BNT116 and LungVax are nucleic acid lung cancer vaccine candidates – the former is based on mRNA technology similar to “COVID-19 mRNA vaccines” such as BNT162b2 of Pfizer/BioNTech and Moderna’s mRNA-1273 while the LungVax vaccine is similar to Oxford/AstraZeneca...
Monoclonal antibodies (mAbs) lecanemab and donanemab have been approved for the treatment of early Alzheimer’s disease in the UK and USA respectively while lecanemab has been refused marketing authorisation in the EU in view of “unsatisfactory” safety and efficacy...
The monkeypox virus (MPXV), called so because of its first discovery in monkeys kept in research facility in Denmark, is closely related to variola virus that causes smallpox. It is responsible for monkeypox (mpox) disease that has gradually emerged...
The upsurge of mpox in the Democratic Republic of the Congo (DRC) and in many other countries in Africa has been determined by WHO to constitute a public health emergency of international concern (PHEIC) under the International Health Regulations...
In view of serious and growing outbreak of monkeypox (Mpox) disease in the Democratic Republic of the Congo (DRC) that has now spread outside the country and detection of the new strain that first emerged in September 2023 outside DRC,...
Neffy (epinephrine nasal spray) has been approved by the FDA for the emergency treatment of Type I allergic reactions including life-threatening anaphylaxis. This provides an alternative route of administration of epinephrine to those (especially children) averse to injections and...
Tecelra (afamitresgene autoleucel), a gene therapy for the treatment of adults with metastatic synovial sarcoma has been approved by the FDA. The approval was based on assessment of safety and effectiveness in a multicentre, open-label clinical trial. It is...
Current antibiotics used in clinical practice, in addition to neutralising target pathogens also harm healthy bacteria in the gut. The disturbance in gut microbiome has toxic effects on liver, kidney and other organs. This is an issue to be addressed....
An investigation of the rapid monkeypox (MPXV) outbreak that emerged in October 2023 in the Kamituga region of the Democratic Republic of the Congo (DRC) has revealed that sexual contact was a key mode of transmission of infection. This...
The broad-spectrum fifth-generation cephalosporin antibiotic, Zevtera (Ceftobiprole medocaril sodium Inj.) has been approved by FDA1 for the treatment of three diseases viz.   Staphylococcus aureus bloodstream infections (bacteremia) (SAB), including those with right-sided infective endocarditis;   acute bacterial skin and skin structure infections (ABSSSI);...
Rezdiffra (resmetirom) has been approved by the FDA of the USA for the treatment of adults with noncirrhotic non-alcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), to be used along with diet and exercise.   Until now, patients with...
World Health Organization (WHO) has published a new, comprehensive diagnostic manual for mental, behavioural, and neurodevelopmental disorders. This will help qualified mental health and other health professionals to identify and diagnose mental, behavioural and neurodevelopmental disorders in clinical settings...
In February 2024, five countries in the WHO European region (Austria, Denmark, Germany, Sweden and The Netherlands) reported an unusual increase in psittacosis cases in 2023 and at the beginning of 2024, particularly marked since November-December 2023. Five deaths...
Iloprost, a synthetic prostacyclin analog used as vasodilator to treat pulmonary arterial hypertension (PAH), has been approved by the U.S. Food and Drug Administration for treatment of severe frostbite. This is first approved medication in the USA to treat...
Antibiotic resistance particularly by Gram-negative bacteria has nearly created a crisis like situation. The novel antibiotic Zosurabalpin (RG6006) shows promises. It has been found to be effective against drug-resistant, Gram-negative bacteria CRAB in pre-clinical studies.    Antimicrobial resistance (AMR), driven mainly by...

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